JAMA : the journal of the American Medical Association
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A large number of epidemiologic studies have reported on associations between various "inflammatory" factors and coronary heart disease (CHD). ⋯ The published results from these prospective studies are remarkably consistent for each factor, indicating moderate but highly statistically significant associations with CHD. Hence, even though mechanisms that might account for these associations are not clear, further study of the relevance of these factors to the causation of CHD is warranted.