JAMA : the journal of the American Medical Association
-
Randomized Controlled Trial Multicenter Study Clinical Trial
Treatment of antidepressant-associated sexual dysfunction with sildenafil: a randomized controlled trial.
Sexual dysfunction is a common adverse effect of antidepressants that frequently results in treatment noncompliance. ⋯ In our study, sildenafil effectively improved erectile function and other aspects of sexual function in men with sexual dysfunction associated with the use of SRI antidepressants. These improvements may allow patients to maintain adherence with effective antidepressant treatment.
-
Randomized Controlled Trial Clinical Trial
Prophylactic treatment of migraine with an angiotensin II receptor blocker: a randomized controlled trial.
There is a paucity of effective, well-tolerated drugs available for migraine prophylaxis. ⋯ In this study, the angiotensin II receptor blocker candesartan provided effective migraine prophylaxis, with a tolerability profile comparable with that of placebo.