JAMA : the journal of the American Medical Association
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Meta Analysis
Association between influenza vaccination and cardiovascular outcomes in high-risk patients: a meta-analysis.
Among nontraditional cardiovascular risk factors, recent influenzalike infection is associated with fatal and nonfatal atherothrombotic events. ⋯ In a meta-analysis of RCTs, the use of influenza vaccine was associated with a lower risk of major adverse cardiovascular events. The greatest treatment effect was seen among the highest-risk patients with more active coronary disease. A large, adequately powered, multicenter trial is warranted to address these findings and assess individual cardiovascular end points.