JAMA : the journal of the American Medical Association
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Observational Study
Association Between Alendronate Use and Hip Fracture Risk in Older Patients Using Oral Prednisolone.
Oral glucocorticoid treatment increases fracture risk, and evidence is lacking regarding the efficacy of alendronate to protect against hip fracture in older patients using glucocorticoids. ⋯ Among older patients using medium to high doses of prednisolone, alendronate treatment was associated with a significantly lower risk of hip fracture over a median of 1.32 years. Although the findings are limited by the observational study design and the small number of events, these results support the use of alendronate in this patient group.