JAMA : the journal of the American Medical Association
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It remains uncertain whether nebulization of mucolytics with bronchodilators should be applied for clinical indication or preventively in intensive care unit (ICU) patients receiving invasive ventilation. ⋯ Among ICU patients receiving invasive ventilation who were expected to not be extubated within 24 hours, on-demand compared with routine nebulization of acetylcysteine with salbutamol did not result in an inferior number of ventilator-free days. On-demand nebulization may be a reasonable alternative to routine nebulization.
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Editorial Comment Comparative Study
Challenges in Understanding Differences in Health Care Spending Between the United States and Other High-Income Countries.