JAMA : the journal of the American Medical Association
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Childhood lead exposure has been linked to disrupted brain development, but long-term consequences for structural brain integrity are unknown. ⋯ In this longitudinal cohort study with a median 34-year follow-up, higher childhood blood lead level was associated with differences in some MRI measures of brain structure that suggested lower structural brain integrity in midlife. Because of the large number of statistical comparisons, some findings may represent type I error.