British journal of clinical pharmacology
-
Br J Clin Pharmacol · Mar 1999
Randomized Controlled Trial Clinical TrialPharmacokinetic profile of alniditan nasal spray during and outside migraine attacks.
To compare the pharmacokinetic profile of intranasal alniditan during and outside migraine attacks, and to investigate the relationship between initial rise of alniditan plasma concentration, and headache improvement. ⋯ Absorption of alniditan nasal spray was not affected by migraine attacks, although 95% confidence intervals were wide. Early rise of plasma concentrations and the amount of drug in the circulation were related to headache improvement in the higher dose group.