Neuroscience letters
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Neuroscience letters · Apr 2013
Randomized Controlled TrialA preliminary study of the effects of ulinastatin on early postoperative cognition function in patients undergoing abdominal surgery.
Ulinastatin, a urinary trypsin inhibitor, is widely used to treat acute systemic inflammatory disorders. However, its effects on early postoperative cognitive function have not been fully elucidated. The objective of this study was to investigate the effect of ulinastatin on serum IL-6, TNF-α, CRP and S100β protein concentration and early postoperative cognitive function in patients after abdominal surgery. ⋯ Ulinastatin may be effective in reducing the incidence of early postoperative cognitive dysfunction.