The New England journal of medicine
The most recent articles from:
N. Engl. J. Med.
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Editorial Comment
Antioxidant therapy for idiopathic pulmonary fibrosis.
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Randomized Controlled Trial Multicenter Study
Sildenafil citrate therapy for pulmonary arterial hypertension.
Sildenafil inhibits phosphodiesterase type 5, an enzyme that metabolizes cyclic guanosine monophosphate, thereby enhancing the cyclic guanosine monophosphate-mediated relaxation and growth inhibition of vascular smooth-muscle cells, including those in the lung. ⋯ Sildenafil improves exercise capacity, WHO functional class, and hemodynamics in patients with symptomatic pulmonary arterial hypertension.