The New England journal of medicine
-
Randomized Controlled Trial Multicenter Study Clinical Trial
A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women.
Randomized trials have shown that low-dose aspirin decreases the risk of a first myocardial infarction in men, with little effect on the risk of ischemic stroke. There are few similar data in women. ⋯ In this large, primary-prevention trial among women, aspirin lowered the risk of stroke without affecting the risk of myocardial infarction or death from cardiovascular causes, leading to a nonsignificant finding with respect to the primary end point.
-
Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis.
Atherosclerotic intracranial arterial stenosis is an important cause of stroke. Warfarin is commonly used in preference to aspirin for this disorder, but these therapies have not been compared in a randomized trial. ⋯ Warfarin was associated with significantly higher rates of adverse events and provided no benefit over aspirin in this trial. Aspirin should be used in preference to warfarin for patients with intracranial arterial stenosis.