The New England journal of medicine
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Randomized Controlled Trial Comparative Study Clinical Trial
A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus.
It is uncertain whether the administration of benzodiazepines by paramedics is an effective and safe treatment for out-of-hospital status epilepticus. ⋯ Benzodiazepines are safe and effective when administered by paramedics for out-of-hospital status epilepticus in adults. Lorazepam is likely to be a better therapy than diazepam.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer.
Short-term preoperative radiotherapy and total mesorectal excision have each been shown to improve local control of disease in patients with resectable rectal cancer. We conducted a multicenter, randomized trial to determine whether the addition of preoperative radiotherapy increases the benefit of total mesorectal excision. ⋯ Short-term preoperative radiotherapy reduces the risk of local recurrence in patients with rectal cancer who undergo a standardized total mesorectal excision.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Effect of prone positioning on the survival of patients with acute respiratory failure.
Although placing patients with acute respiratory failure in a prone (face down) position improves their oxygenation 60 to 70 percent of the time, the effect on survival is not known. ⋯ Although placing patients with acute respiratory failure in a prone position improves their oxygenation, it does not improve survival.