The New England journal of medicine
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Multicenter Study Clinical Trial
Aspirin and mortality from coronary bypass surgery.
There is no therapy known to reduce the risk of complications or death after coronary bypass surgery. Because platelet activation constitutes a pivotal mechanism for injury in patients with atherosclerosis, we assessed whether early treatment with aspirin could improve survival after coronary bypass surgery. ⋯ Early use of aspirin after coronary bypass surgery is safe and is associated with a reduced risk of death and ischemic complications involving the heart, brain, kidneys, and gastrointestinal tract.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism.
The use of thrombolytic agents in the treatment of hemodynamically stable patients with acute submassive pulmonary embolism remains controversial. ⋯ When given in conjunction with heparin, alteplase can improve the clinical course of stable patients who have acute submassive pulmonary embolism and can prevent clinical deterioration requiring the escalation of treatment during the hospital stay.