The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Comparative Study
Rivaroxaban in Patients with Atrial Fibrillation and a Bioprosthetic Mitral Valve.
The effects of rivaroxaban in patients with atrial fibrillation and a bioprosthetic mitral valve remain uncertain. ⋯ In patients with atrial fibrillation and a bioprosthetic mitral valve, rivaroxaban was noninferior to warfarin with respect to the mean time until the primary outcome of death, major cardiovascular events, or major bleeding at 12 months. (Funded by PROADI-SUS and Bayer; RIVER ClinicalTrials.gov number, NCT02303795.).
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Letter Randomized Controlled Trial
N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects.
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Randomized Controlled Trial Multicenter Study Comparative Study
Once-Weekly Insulin for Type 2 Diabetes without Previous Insulin Treatment.
It is thought that a reduction in the frequency of basal insulin injections might facilitate treatment acceptance and adherence among patients with type 2 diabetes. Insulin icodec is a basal insulin analogue designed for once-weekly administration that is in development for the treatment of diabetes. ⋯ Once-weekly treatment with insulin icodec had glucose-lowering efficacy and a safety profile similar to those of once-daily insulin glargine U100 in patients with type 2 diabetes. (Funded by Novo Nordisk; NN1436-4383 ClinicalTrials.gov number, NCT03751657.).