The New England journal of medicine
The most recent articles from:
N. Engl. J. Med.
2022
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Randomized Controlled Trial Comparative Study Pragmatic Clinical Trial
Chlorthalidone vs. Hydrochlorothiazide for Hypertension-Cardiovascular Events.
Whether chlorthalidone is superior to hydrochlorothiazide for preventing major adverse cardiovascular events in patients with hypertension is unclear. ⋯ In this large pragmatic trial of thiazide diuretics at doses commonly used in clinical practice, patients who received chlorthalidone did not have a lower occurrence of major cardiovascular outcome events or non-cancer-related deaths than patients who received hydrochlorothiazide. (Funded by the Veterans Affairs Cooperative Studies Program; ClinicalTrials.gov number, NCT02185417.).