The New England journal of medicine
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Randomized Controlled Trial Comparative Study
Weekly Icodec versus Daily Glargine U100 in Type 2 Diabetes without Previous Insulin.
Insulin icodec is an investigational once-weekly basal insulin analogue for diabetes management. ⋯ Glycemic control was significantly better with once-weekly insulin icodec than with once-daily insulin glargine U100. (Funded by Novo Nordisk; ONWARDS 1 ClinicalTrials.gov number, NCT04460885.).
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Randomized Controlled Trial Multicenter Study Comparative Study
Preoperative Treatment of Locally Advanced Rectal Cancer.
Pelvic radiation plus sensitizing chemotherapy with a fluoropyrimidine (chemoradiotherapy) before surgery is standard care for locally advanced rectal cancer in North America. Whether neoadjuvant chemotherapy with fluorouracil, leucovorin, and oxaliplatin (FOLFOX) can be used in lieu of chemoradiotherapy is uncertain. ⋯ In patients with locally advanced rectal cancer who were eligible for sphincter-sparing surgery, preoperative FOLFOX was noninferior to preoperative chemoradiotherapy with respect to disease-free survival. (Funded by the National Cancer Institute; PROSPECT ClinicalTrials.gov number, NCT01515787.).