Neuroscience
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With the deepening of population aging, the treatment of cognitive impairment and dementia is facing increasing challenges. Vascular dementia (VaD) is a cognitive dysfunction caused by brain blood flow damage and one of the most common causes of dementia after Alzheimer's disease. White matter damage in patients with chronic ischemic dementia often occurs before cognitive impairment, and its pathological changes include leukoaraiosis, myelin destruction and oligodendrocyte death. ⋯ The current proposed mechanisms include calcium overload, oxidative stress, nitrative stress and inflammatory damage, which can lead to hypoxia-ischemia and demyelination. Oligodendrocytes are the only myelinating cells in the central nervous system and closely associated with VaD. In this review article, we intend to further discuss the role of oligodendrocytes in white matter and myelin injury in VaD and the development of anti-myelin injury target drugs.
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Randomized Controlled Trial
A causal role of right TPJ in prosocial learning: a tDCS study.
Prosocial behavior is a common and important aspect of everyday social life. To behave prosocially, we need to learn the consequences of our actions for other people, known as prosocial learning. Previous studies have identified the right temporoparietal junction (rTPJ) as the critical neurological substrate for prosocial behavior. ⋯ Participants were able to learn to obtain rewards for themselves or others, and learning performance in the self-learning condition was better than that in the prosocial-learning condition. However, anodal tDCS over the rTPJ significantly improved learning performance in the prosocial-learning condition. These results indicate that the rTPJ plays a causal role in prosocial learning.
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There is increasing evidence that major trauma can adversely affect the brain and cognition. In some cases, trauma may lead to deficits in executive function (EF). The anterior insula may be a causal outflow hub acting to coordinate EF-related brain networks. ⋯ No correlation was found between abnormal connectivity and cognitive/post-traumatic stress symptoms in participants with EFD. These results suggest that excessive connections between the insula and DMN could contribute to EFD after trauma. Overall, this study provides novel references into the neural mechanisms of EF status after trauma exposure.
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In the field of brain-to-text communication, it is difficult to finish highly dexterous behaviors of writing multi-character by motor-imagery-based brain-computer interface (MI-BCI), setting a barrier to restore communication in people who have lost the ability to move and speak. In this paper, we design and implement a multi-character classification scheme based on 29 characters of motor imagery (MI) electroencephalogram (EEG) signals, which contains 26 English letters and 3 punctuation marks. Firstly, we design a novel experimental paradigm to increase the variety of BCI inputs by asking subjects to imagine the movement of writing 29 characters instead of gross motor skills such as reaching or grasping. ⋯ Thirdly, we respectively employ k-nearest neighbor (kNN), support vector machine (SVM), extreme learning machine (ELM) and light gradient boosting machine (LightGBM) to classify 29 characters and compare the results. We have implemented a complete scheme, including paradigm design, signal acquisition, feature extraction and classification, which can effectively classify 29 characters. The experimental results show that the KPCA has the best feature extraction effect and the kNN has the highest classification accuracy, with the final classification accuracy reaching 96.2%, which is better than other studies.
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ECHDC3 is a risk gene for white matter (WM) hyperintensity and is associated with insulin resistance. This study aimed to investigate whether ECHDC3 variants selectively regulate brain WM microstructures and episodic memory in patients with type 2 diabetes mellitus (T2DM). We enrolled 106 patients with T2DM and 111 healthy controls. ⋯ We observed a noteworthy interaction between genotype and diagnosis on FA in the right inferior temporal WM, right anterior limb of the internal capsule, right frontal WM, and the right hippocampus. Modulated mediation analysis revealed a significant ECHDC3 modulation on the T2DM → right hippocampal FA → short-term memory pathway, with only rs11257311 G risk homozygote demonstrating significant mediation effect. Together, our findings provide evidence of ECHDC3 modulating the effect of T2DM on right hippocampal microstructural impairment and short-term memory decline, which might be a neuro-mechanism for T2DM related episodic memory impairment.