Clinical and experimental dermatology
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Clin. Exp. Dermatol. · Jul 2019
Meta AnalysisVitamin D receptor ApaI, TaqI, BsmI, and FokI polymorphisms and psoriasis susceptibility: an updated meta-analysis.
Vitamin D is considered a regulator of the immune system, and its polymorphisms have been associated with psoriasis in some but not all reports. ⋯ This meta-analysis showed that polymorphisms in VDR ApaI, BsmI and FokI are not associated with psoriasis susceptibility in overall, Caucasian or Asian populations. However, the VDR TaqI polymorphism is associated with psoriasis susceptibility in Caucasian populations.
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Clin. Exp. Dermatol. · Dec 2013
Meta AnalysisAssociation of the tumour necrosis factor-α polymorphisms rs361525 and rs1800629 with susceptibility to psoriasis: a meta-analysis.
Evidence has suggested that tumour necrosis factor (TNF)-α may be involved in the aetiology of psoriasis, but the underlying association of the TNF-α polymorphisms -238G/A (rs361525) and -308G/A (rs1800629) with the risk of psoriasis is still unconfirmed. ⋯ This meta-analysis suggests that the TNF-α -238 and -308 promoter polymorphisms may play different roles in conferring susceptibility to psoriasis. Functional and well-designed studies should be conducted to confirm these results.