Spine
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Meta-analysis of randomized controlled trials. ⋯ 1.
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Meta Analysis
Aggrecan variable number of tandem repeat polymorphism and lumbar disc degeneration: a meta-analysis.
Data on the association between the ACAN (encoded for aggrecan core protein) variable number of tandem repeat (VNTR) polymorphism and lumbar disc degeneration are conflicting, so we performed a meta-analysis. ⋯ Our results suggest an increased risk of shorter alleles compared with normal alleles and longer alleles against lumbar disc degeneration among populations especially among Asian descent. Such association may not be statistically significant in European populations.