Spine
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Survey report. ⋯ Changes in research priorities seem to reflect recent advances, new opportunities, and limitations in our ability to improve care.
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Basic imaging experiment. ⋯ We conclude that DTT could be useful for detecting the early changes associated with the compressed spinal cord in cervical ossification of the posterior longitudinal ligament.
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An in vitro study with bovine intervertebral disc (IVD) cells and an in vivo study with a rabbit disc degeneration model on the extracellular matrix metabolism by a biglycan-derived peptide (Peniel 2000; P2K). ⋯ A novel peptide, P2K, regulating TGF-β1 signaling had an anabolic effect on bovine IVD cells and rabbit degenerated discs. The results suggest that P2K has considerable potential as a treatment of degenerative disc disease.
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Retrospective cohort study of health care costs associated with the treatment of chronic low back pain (CLBP) in the United Kingdom. ⋯ Our findings confirm the substantial economic burden of CLBP, even with direct costs only.