Intensive care medicine
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Intensive care medicine · Feb 2024
Venous thromboembolism in critically ill adult patients with hematologic malignancy: a population-based cohort study.
The aim of this study was to describe the incidence of venous thromboembolism (VTE) and major bleeding among hospitalized patients with hematologic malignancy, assessing its association with critical illness and other baseline characteristics. ⋯ Among patients with hematologic malignancy, critical illness and certain baseline characteristics were associated with a higher incidence of VTE.
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Intensive care medicine · Feb 2024
Randomized Controlled Trial Multicenter StudyEffect of aggressive vs conservative screening and confirmatory test on time to extubation among patients at low or intermediate risk: a randomized clinical trial.
This study aimed to determine the best strategy to achieve fast and safe extubation. ⋯ Among patients at low or intermediate risk for extubation failure with planned HFNC, combining aggressive screening with preventive PEEP and a conservative SBT reduced the time to extubation without increasing the reintubation rate.
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Intensive care medicine · Feb 2024
Meta AnalysisMechanical circulatory support for cardiogenic shock: a network meta-analysis of randomized controlled trials and propensity score-matched studies.
Cardiogenic shock is associated with high mortality. In refractory shock, it is unclear if mechanical circulatory support (MCS) devices improve survival. We conducted a network meta-analysis to determine which MCS devices confers greatest benefit. ⋯ In patients with cardiogenic shock, ECMO-IABP may reduce mortality, while other MCS devices did not reduce mortality. However, this must be interpreted within the context of inter-study heterogeneity and limited certainty of evidence.
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Intensive care medicine · Feb 2024
Multicenter StudyAcute kidney disease beyond day 7 after major surgery: a secondary analysis of the EPIS-AKI trial.
Acute kidney disease (AKD) is a significant health care burden worldwide. However, little is known about this complication after major surgery. ⋯ One in ten major surgery patients developed AKD beyond 7 days after surgery, in most cases without an episode of early postoperative-AKI. However, early postoperative-AKI severity and duration were associated with an increased rate of AKD and early postoperative-AKI was strongly associated with AKD independent of all other potential risk factors.