Neurosurgery
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Randomized Controlled Trial
Randomized pilot trial of intensive management of blood pressure or volume expansion in subarachnoid hemorrhage (IMPROVES).
Volume expansion and hypertension are widely used for the hemodynamic management of patients with subarachnoid hemorrhage. ⋯ This pilot study showed adequate feasibility and excellent retention to follow-up. Given the suggestion of possible worse neurobehavioral outcome with ABP, a larger trial to determine the optimal blood pressure management in this patient population is warranted. (ClinTrials.gov NCT01414894.)
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Randomized Controlled Trial
Contralateral peripheral neurotization for hemiplegic upper extremity after central neurologic injury.
Central neurological injury (CNI) is a major contributor to physical disability that affects both adults and children all over the world. The main sequelae of chronic stage CNI are spasticity, paresis of specific muscles, and poor selective motor control. Here, we apply the concept of contralateral peripheral neurotization in spasticity releasing and motor function restoration of the affected upper extremity. ⋯ This contralateral C7 neurotization approach may open a door to promote functional recovery of upper extremity paralysis after CNI.