Irish journal of medical science
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The Runx family proteins, including RUNX3, are tissue-restricted transcription factors and play role in neuronal development and tumorigenesis. RUNX3 has an important role in glioblastoma (GBM) tumorigenesis because of its promoter hypermethylation. ⋯ This study overemphasized the RUNX3 gene importance in brain tumors, due to the existence of at least one methylated allele.
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To characterise a cohort of patients with chronic pain registered to the Ulysses cognitive behavioural pain management programme (CBT-PMP) and to evaluate the effectiveness of the CBT-PMP 6 months post-discharge. ⋯ The effectiveness of the Ulysses CBT-PMP is established with measures of clinically significant change for physical and psychological outcomes contributing to the evidence for this novel approach of analysis. Future research determining benchmarks for CBT-PMP outcomes will assist clinicians in monitoring and enhancing patient's progress in clinical practice.
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Evaluation of a new systems-based curriculum in an undergraduate Irish Medical School was carried out with the validated Dundee Ready Educational Environment (DREEM) inventory. Comparison was made with the results from a previous DREEM study in the old curriculum. ⋯ DREEM is a valuable tool in evaluating the educational environment and monitoring the impact of curricular change.
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Intrathecal opioid administration yields high quality analgesia with an associated low incidence of side effects and complication. The benefits of spinal "opioid only technique" include absence of neuronal blockade, infusion pump malfunction and sympathetic blockade. This technique declined after serious side effects were reported in the 1990s. ⋯ Intrathecal morphine for post-op analgesia is efficacious and safe in a post-thoracotomy population.