Médecine et maladies infectieuses
The most recent articles from:
Med Mal Infect
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Randomized Controlled Trial Multicenter Study Comparative Study
The ZEPHyR study: a randomized comparison of linezolid and vancomycin for MRSA pneumonia.
Methicillin-resistant Staphylococcus aureus (MRSA) accounts for 10-40% of hospital-acquired pneumonia, and even more in intensive care units. The current guidelines for the treatment of MRSA nosocomial pneumonia include vancomycin and linezolid. The authors of 2 prospective randomized trials comparing vancomycin and linezolid in nosocomial pneumonia had concluded to the non-inferiority of linezolid. A slight superiority of linezolid was observed in the MRSA pneumonia subgroup, in terms of clinical success and survival, but no definite conclusion could be drawn. ⋯ LNZ was superior to vancomycin for the treatment of MRSA nosocomial pneumonia.