Neurological research
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Neurological research · May 2016
Correlative factors of cognitive dysfunction in PD patients: a cross-sectional study from Southwest China.
Cognitive dysfunction is common in Parkinson's disease (PD). A comprehensive understanding of cognitive dysfunction and its correlative factors in Chinese PD patients were not available. ⋯ Age, sex, education level, bradykinesia score, and presence of urinary symptoms are correlative factors of cognitive dysfunction in Chinese PD patients.
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Neurological research · May 2016
Internal maxillary artery to intracranial artery bypass: a case series of 31 patients with chronic internal carotid/middle cerebral arterial-sclerotic steno-occlusive disease.
To evaluate the effectiveness of internal maxillary artery (IMA) - radial artery graft (RAG) - middle cerebral artery (MCA) bypass surgery for chronic arterial-sclerotic severe stenosis or occlusion of the internal carotid artery (ICA) or MCA. ⋯ By supplying an adequate flow to a larger flow territory of chronically stenotic/occlusive major cerebral arteries, IMA bypass surgery is efficient for restoring hemodynamics in selected patients and improving their neurological deficits.
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Neurological research · Apr 2016
Restless leg syndrome: a risk factor of higher prevalence of anxiety and depression in Parkinson's disease patients.
Many studies have assessed the relationship of depression and anxiety with Parkinson's disease (PD), as well as examining restless leg syndrome (RLS) with depression and anxiety. Nonetheless, there has not been an extensive effort to show how the prevalence of RLS affects both depression and anxiety in PD patients. The objective of this study was to examine how the prevalence of RLS in PD patients affects the prevalence and severity of depression and anxiety and how they compare with each other. This study is the first of its kind that examines the effects of the combination of the two neurological conditions with depression and anxiety as well as comparing their prevalence and severity to each other. ⋯ The presence of RLS in PD patients may increase the occurrence of both anxiety and depression, but the severity of the symptoms is not significant in the two groups of the PD patients.
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Neurological research · Mar 2016
Sciatic nerve regeneration in KLF7-transfected acellular nerve allografts.
Krüppel-like Factor 7 (KLF7) is a transcription factor that promotes axon regeneration in the central nervous system. Here, we assessed whether KLF7 stimulates regeneration after peripheral nerve injury. ⋯ Our findings suggest that KLF7 promoted peripheral nerve axonal regeneration, further supporting a role for KLF7 as a growth-promoting transcription factor in the injured nervous system.
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Neurological research · Mar 2016
Traumatic brain injury accelerates kindling epileptogenesis in rats.
Traumatic brain injury (TBI) is a well-known cause of symptomatic epilepsy. In animal models of post-traumatic epilepsy (PTE), progression of trauma to epilepsy takes several weeks to months. Although this long process is similar to clinical PTE, it is costly and laborious. We used a combination of TBI and kindling as an accelerated animal model to develop epilepsy in much shorter period compared to that occurring in PTE. ⋯ Traumatic brain injury facilitates acquisition of epilepsy in both chemical and electrical kindling models. Combination of trauma and kindling can be considered as an inexpensive and time-saving animal model in PTE studies.