Annals of emergency medicine
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Review Meta Analysis
The relative efficacy of meperidine for the treatment of acute migraine: a meta-analysis of randomized controlled trials.
Despite guidelines recommending against opioids as first-line treatment for acute migraine, meperidine is the agent used most commonly in North American emergency departments. Clinical trials performed to date have been small and have not arrived at consistent conclusions about the efficacy of meperidine. We performed a systematic review and meta-analysis to determine the relative efficacy and adverse effect profile of opioids compared with nonopioid active comparators for the treatment of acute migraine. ⋯ Clinicians should consider alternatives to meperidine when treating acute migraine with injectable agents.