Thrombosis research
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Thrombosis research · Dec 2012
ReviewSystematic review: 3-factor versus 4-factor prothrombin complex concentrate for warfarin reversal: does it matter?
Prothrombin complex concentrates are used for rapid reversal of vitamin K antagonists in patients with bleeding or those requiring surgery or invasive procedures. Current guidelines suggest 4-factor products are preferred over 3-factor prothrombin complex concentrates. ⋯ More reliable correction of the international normalized ratio was seen with 4-factor compared to 3-factor prothrombin complex concentrates which may have clinical implications since 4-factor products are unavailable in some countries.