Journal of vascular surgery
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Randomized Controlled Trial Comparative Study
Variability and persistence of aspirin response in lower extremity peripheral arterial disease patients.
To determine the prevalence of poor response to aspirin (ASA) therapy over 12-month follow-up in patients with lower extremity peripheral arterial disease (PAD), and to compare the classification agreement among different ASA response assays. ⋯ Between 5% and 27.5% of PAD patients were Persistent PRs to ASA over 6- to 12-month follow-up using different platelet assays. Further, these commonly used platelet assays show weak agreement in determining poor response to aspirin.