Journal of vascular surgery
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Meta Analysis
Polymorphisms of genes involved in extracellular matrix remodeling and abdominal aortic aneurysm.
Abdominal aortic aneurysm (AAA) has a multifactorial etiology and the relevance of genetic factors is getting increasing interest, in particular those related to the destructive remodeling of extracellular matrix. ⋯ These findings suggest that polymorphisms in MMP2, MMP3, MMP-13, and ELN genes may independently contribute to the pathogenesis of AAA.