European journal of anaesthesiology
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Randomized Controlled Trial Comparative Study Clinical Trial
Target-controlled infusion of remifentanil or fentanyl during extra-corporeal shock-wave lithotripsy.
Target-controlled infusions (TCIs) of remifentanil and fentanyl in conscious sedation regimes for extra-corporeal shock-wave lithotripsy have not been reported. We estimated the effect site concentrations of remifentanil and fentanyl needed to obtain adequate analgesia in 50% of patients (EC50) and compared both drugs in terms of intra- and post-procedure complications. ⋯ A similar EC50 but more respiratory depression, sedation and PONV were found with fentanyl TCI than with remifentanil TCI.
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Randomized Controlled Trial Clinical Trial
Gabexate mesilate hastens recovery from vecuronium-induced neuromuscular blockade.
To test the hypothesis that gabexate mesilate, a protease inihibitor, hastens recovery from neuromuscular blockade, we examined the effect of gabexate mesilate on the recovery of vecuronium-induced neuromuscular blockade in anaesthetized patients in a double-blind, randomized fashion. ⋯ Gabexate mesilate hastens recovery from neuromuscular block in anaesthetized patients receiving vecuronium.
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Comparative Study Clinical Trial
Pharmacokinetics and pharmacodynamics of rocuronium in patients with and without renal failure.
This study clarifies the relationship between the neuromuscular blocking effects of rocuronium 0.6 mg kg(-1) and its pharmacokinetics in patients with renal failure. ⋯ The duration of action of a bolus dose of 0.6 mg kg(-1) rocuronium is increased significantly in patients with end-stage renal failure compared to healthy controls. This increase may be due to a decreased clearance of rocuronium, the disease process causing the renal failure and/or the medication which patients with renal failure need in their treatment.
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Letter Randomized Controlled Trial Clinical Trial
Ketamine pretreatment with venous occlusion attenuates pain on injection with propofol.
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We have evaluated the use of the TOF-Guard (TOF, train-of-four) acceleromyographic thumb responses to ulnar nerve stimulation in neonates and infants and the return of the responses after neuromuscular blockade. ⋯ The recovery of the responses after neuromuscular blockade to near baseline values shows that acceleromyography can be used to measure neuromuscular block and recovery in neonates and infants.