The Clinical journal of pain
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The objective of the study was to assess diffuse noxious inhibitory control (DNIC) function in women with provoked vestibulodynia (PVD) compared with healthy controls through the use of 2 different methodologies. Furthermore, the study aimed to assess whether pain characteristics correlate with DNIC in women with PVD. ⋯ Results support previous findings of intact DNIC function in women with PVD, using both an ascending method of limits and a temporal summation paradigm. Pain-related variables were not correlated with DNIC function in women with PVD, perhaps this unexpected finding is due to the possibility that central processes other than DNIC, such as descending facilitation, provoke or maintain this chronic pain condition.
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Review Case Reports
Use of buprenorphine in children with chronic pseudoobstruction syndrome: case series and review of literature.
Abdominal pain is the most challenging symptom in chronic intestinal pseudoobstruction (CIPO) syndrome, because of its severity and the limited availability of suitable opioid formulations, especially in pediatric patients with digestive problems. Most of the children with CIPO cannot tolerate oral formulations. ⋯ CIPO and the unique pharmacological profile of buprenorphine are reviewed briefly.
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Randomized Controlled Trial Clinical Trial
Low back pain subgroups using fear-avoidance model measures: results of a cluster analysis.
The purpose of this secondary analysis was to test the hypothesis that an empirically derived psychological subgrouping scheme based on multiple Fear-Avoidance Model (FAM) constructs would provide additional capabilities for clinical outcomes in comparison with a single FAM construct. ⋯ These data suggest that subgrouping based on multiple FAM measures may provide additional information on clinical outcomes in comparison with determining subgroup status by FABQ-PA alone. Subgrouping methods for patients with low back pain should include multiple psychological factors to further explore if patients can be matched with appropriate interventions.
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Randomized Controlled Trial Clinical Trial
Interaction of fentanyl and buprenorphine in an experimental model of pain and central sensitization in human volunteers.
: There is controversy about combining opioids with different receptor affinities. We assessed the analgesic and antihyperalgesic effects of the μ-agonist fentanyl and the partial μ-agonist/κ-antagonist buprenorphine in a human pain model, when given alone or in combination. ⋯ : For the doses administered in this study, buprenorphine and fentanyl showed an additive interaction.
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To provide a current overview of the diagnostic work-up and management of painful diabetic polyneuropathy (PDPN). ⋯ As efficacy and tolerability of current therapy for PDPN are not ideal, the need for a better approach in management further exists. Novel compounds should be developed for the treatment of PDPN.