The Clinical journal of pain
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Randomized Controlled Trial
Effects of Adding Oxycodone to Ropivacaine on Labor Analgesia: A Randomized Controlled Trial.
It's known that the addition of opiates to LA improves epidural analgesia in labour. This trial should have compared oxycodone to fentanyl.
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Somatosensory abnormalities are linked to clinical pain outcomes in individuals with spinal pain. However, a range of factors might confound the relationship between altered somatosensory function and clinical pain outcomes. This systematic review aimed to evaluate the literature to assess the level of evidence of associations between psychological, social, physical activity, and sleep measures and somatosensory function (assessed via sensory psychophysical testing) among individuals with spinal pain. ⋯ Psychological factors are associated negatively with pain thresholds and they need to be adjusted when establishing predictive relationships between somatosensory function and pain outcomes in individuals with spinal pain.
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Randomized Controlled Trial
The Benefit of Dexmedetomidine on Postoperative Cognitive Function is Unrelated to the Modulation on Peripheral Inflammation: A Single Center, Prospective, Randomized Study.
Dexmedetomidine potentially confers an advantage to reduce the incidence of postoperative delirium (POD) in surgical patients. Anti-inflammation is important effect of this sedative drug. In this study, we aimed to investigate whether the effect of dexmedetomidine on the postoperative cognitive function is via inhibiting peripheral inflammation. ⋯ Intraoperative sedation with dexmedetomidine conferred better postoperative neurocognitive function for elderly patients who received total knee arthroplasty. This effect was unrelated to the modulation of dexmedetomidine on peripheral inflammation.
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The objective of the review is to determine whether conditioned pain modulation (CPM) is impaired in adults with chronic low back pain (CLBP) when compared with pain-free individuals. ⋯ High-quality research is strongly recommended to determine the function of endogenous pain modulatory mechanisms in CLBP.