Journal of general internal medicine
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Meta Analysis
The efficacy of selective serotonin reuptake inhibitors for the management of chronic pain.
To assess the effectiveness of selective serotonin reuptake inhibitors (SSRIs) in the management of chronic pain. ⋯ SSRIs appear to be beneficial for mixed-chronic pain. It is unclear, from the available evidence, whether SSRIs are beneficial for migraine headaches, tension headaches, diabetic neuropathy, or fibromyalgia. For those patients it may be reasonable to reserve SSRIs for those who fall to respond to other medications or who are intolerant of their side effects.