Journal of critical care
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Journal of critical care · Feb 2019
Randomized Controlled TrialExtracorporeal cytokine adsorption in septic shock: A proof of concept randomized, controlled pilot study.
The aim of this proof of concept, prospective, randomized pilot trial was to investigate the effects of extracorporeal cytokine removal (CytoSorb®) applied as a standalone treatment in patients with septic shock. ⋯ This is the first trial to investigate the effects of early extracorporeal cytokine adsorption treatment in septic shock applied without renal replacement therapy. It was found to be safe with significant effects on norepinephrine requirements, PCT and Big-endothelin-1 concentrations compared to controls.