Critical care medicine
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Critical care medicine · Jan 1996
Multicenter StudySimplified Therapeutic Intervention Scoring System: the TISS-28 items--results from a multicenter study.
To validate a simplified version of the Therapeutic Intervention Scoring System, the TISS-28, and to determine the association of TISS-28 with the time spent on scored and nonscored nursing activities. ⋯ The simplified TISS-28 explains 86% of the variation in TISS-76 and can therefore replace the original version in the clinical practice in the ICU. Per shift, a typical nurse is capable of delivering nursing activities equal to 46 TISS-28 points.
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Critical care medicine · Jan 1996
Clinical TrialInitial experience with partial liquid ventilation in pediatric patients with the acute respiratory distress syndrome.
Liquid ventilation with perfluorocarbon previously has not been reported in pediatric patients with respiratory failure beyond the neonatal period. We evaluated the technique of partial liquid ventilation in six pediatric patients with the acute respiratory distress syndrome of sufficient severity to require extracorporeal life support (ECLS). ⋯ Perfluorocarbon may be safely administered into the lungs of pediatric patients with severe respiratory failure on ECLS and may be associated with improvement in gas exchange and pulmonary compliance.
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Critical care medicine · Jan 1996
Single breath CO2 analysis: description and validation of a method.
To evaluate the performance of a newly developed single breath CO2 analysis station in measuring the airway deadspace in a lung model (study 1), and then to quantify the bias and precision of the physiologic deadspace measurement in a surfactant-depleted animal model (study 2). ⋯ Our initial experience with the single breath CO2 analysis station indicates that this device can reliably provide on-line evaluation of the single-breath CO2 waveform. In particular, estimation of the airway and physiologic deadspace under a variety of testing conditions was consistently within 5% of actual values. We feel that with further application and refinement of the technique, single breath CO2 analysis may provide a noninvasive, on-line monitor of changes in pulmonary blood flow.
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Critical care medicine · Jan 1996
Comment Letter Comparative StudyPropofol vs. midazolam for sedation.
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Critical care medicine · Jan 1996
Randomized Controlled Trial Multicenter Study Clinical TrialLiposomal prostaglandin E1 in acute respiratory distress syndrome: a placebo-controlled, randomized, double-blind, multicenter clinical trial.
To evaluate the safety and efficacy of liposomal prostaglandin E1 (TLC C-53) in the treatment of patients with the acute respiratory distress syndrome (ARDS). ⋯ In patients with ARDS, TLC C-53 was associated with improved oxygenation, increased lung compliance, and decreased ventilator dependency.