Critical care medicine
-
Critical care medicine · Mar 2015
Thrombocytopenia Impairs Host Defense During Murine Streptococcus pneumoniae Pneumonia.
Streptococcus pneumoniae is the most common causative pathogen in community-acquired pneumonia. In patients, thrombocytopenia is correlated with an adverse outcome of pneumonia. Platelets can modulate the host response to infection in several ways, that is, by facilitating clot formation, production of antimicrobial proteins, and interaction with neutrophils. We studied the effect of thrombocytopenia during murine pneumococcal pneumonia. ⋯ Platelets play a protective role during pneumococcal pneumonia independent of their aggregation.
-
Critical care medicine · Mar 2015
Editorial CommentDigital decoding of pediatric traumatic brain injury*.