Journal of anesthesia
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Journal of anesthesia · Apr 2016
Randomized Controlled TrialEfficacy of dexmedetomidine as an adjuvant in paravertebral block in breast cancer surgery.
This study evaluated the analgesic efficacy of dexmedetomidine in combination with bupivacaine for single-shot paravertebral block (PVB) in patients undergoing major breast cancer surgery. ⋯ PVB using dexmedetomidine 1 µg/kg added to 0.5 % bupivacaine in patients undergoing major breast cancer surgery under GA provides analgesia of longer duration with decreased postoperative opioid consumption and lower incidence of nausea/vomiting compared to PVB with bupivacaine alone or no PVB.
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Journal of anesthesia · Apr 2016
Randomized Controlled TrialEffect of intraoperative application of ketamine on postoperative depressed mood in patients undergoing elective orthopedic surgery.
A depressed mood frequently occurs in perioperative patients, negatively impacting patient recovery. Recent studies suggested that ketamine has a rapid, obvious, and persistent antidepressant effect. The purpose of this study was to investigate the impact of intraoperative application of ketamine on postoperative depressive mood in patients undergoing elective orthopedic surgery. ⋯ Intraoperative application of ketamine was associated with improved scores for depressed mood and increased serum BDNF levels in patients undergoing elective orthopedic surgery.