Der Schmerz
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Historical Article
[From willow bark to the coxibs. Development of antiphlogistic analgesics].
Antiphlogistic analgesics comprise the most widely used class of drugs worldwide. These compounds derive more or less directly from three prototypes which were discovered about 130 years ago in Central Europe: acetylsalicylic acid (aspirin), acetanilide (the forerunner of acetaminophen), and phenazone. All of them are still available. ⋯ They may, on the other hand, cause more unwanted cardiovascular effects than the traditional NSAIDs. Hope for further reduction of unwanted drug effects comes from the recently discovered role of glycinergic spinal pain control. It is hoped that new classes of analgesic compounds may result from these new glycinergic mechanisms.
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Editorial Historical Article
[Twenty years of Der Schmerz. Consolidate and expand].
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Editorial Historical Article
[Twenty years of Der Schmerz. A personal look retrospect].