Annals of medicine
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Randomized Controlled Trial
Peptide hormones and risk for future cardiovascular events among prediabetics: a 20-year follow-up in the OPERA study.
Background: Prediabetes has proven to have many unfavourable impacts on the cardiovascular system. Methods: The OPERA (Oulu Project Elucidating Risk of Atherosclerosis) study included 1045 middle-aged subjects followed from the years 1990-1993 to 2014. The focus was on peptide hormones. ⋯ Among prediabetics, ghrelin seems to predict independently cardiovascular events in the long term. KEY MESSAGEAmong glucose tolerance groups, patients with IGT had the highest resistin, but equally high leptin and low adiponectin levels as diabetics. Among prediabetics, ghrelin seems to predict independently cardiovascular events in the long term.