Pharmacology, biochemistry, and behavior
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Pharmacol. Biochem. Behav. · Jan 2012
Randomized Controlled Trial Clinical TrialSubjective, psychomotor, and physiological effects of pregabalin alone and in combination with oxycodone in healthy volunteers.
Pregabalin is an anticonvulsant drug indicated for neuropathic disorders and fibromyalgia. Some chronic pain patients suffering from these disorders take both this drug and an opioid for pain relief. Pregabalin is a scheduled drug under the Controlled Substances Act. ⋯ When 75 mg pregabalin was combined with oxycodone some subjective effects were altered relative to placebo, in contrast to when each drug was tested alone. Liking of oxycodone was not increased by 75 mg pregabalin. However, recent studies have suggested that this drug is abused, and we would recommend that further psychopharmacological studies with pregabalin are warranted, including a study assessing its abuse liability across a range of doses in sedative abusers.