Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Feb 2007
Randomized Controlled Trial Multicenter StudyDoes esomeprazole prevent post-operative nausea and vomiting?
Esomeprazole is a potent proton pump inhibitor (PPI), reducing acid production as well as gastric juice volume. This study evaluated the possible beneficial effect of esomeprazole on reducing post-operative nausea and vomiting (PONV). ⋯ Esomeprazole had no clinically relevant effect on the overall 24-h incidence of PONV. However, esomeprazole significantly reduced the total amount of vomit during 24-h post-operatively. This may be of value in patients with an increased risk of pulmonary aspiration.