Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Apr 2010
Review Meta AnalysisPremedication with clonidine is superior to benzodiazepines. A meta analysis of published studies.
Premedication is considered important in pediatric anesthesia. Benzodiazepines are the most commonly used premedication agents. Clonidine, an alpha2 adrenoceptor agonist, is gaining popularity among anesthesiologists. The goal of the present study was to perform a meta-analysis of studies comparing premedication with clonidine to Benzodiazepines. ⋯ Premedication with clonidine is superior to midazolam in producing sedation, decreasing post-operative pain and emergence agitation. However, the superiority of clonidine for PONV prevention remains unclear while other factors such as nausea prevention might interfere with this result.