Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Oct 2014
Randomized Controlled TrialCognitive recovery after ambulatory anaesthesia based on desflurane or propofol: a prospective randomised study.
Negative post-anesthetic cognitive effects are still present one week after both desflurane or propofol anesthesia.
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Acta Anaesthesiol Scand · Oct 2014
Review Meta AnalysisProphylactic tranexamic acid in parturients at low risk for post-partum haemorrhage: systematic review and meta-analysis.
Tranexamic acid is effective in reducing blood loss during various types of surgery and after trauma. No compelling evidence has yet been presented for post-partum haemorrhage. A systematic literature search of relevant databases was performed to identify trials that assessed blood loss and transfusion incidence after tranexamic acid administration for post-partum haemorrhage. ⋯ Only four cases of thrombosis were found, two each in the tranexamic acid and control groups. Tranexamic acid effectively reduced post-partum blood loss; the effect on the incidence of blood transfusions requires further studies. Only few trials observed adverse events including thromboembolic complications and seizures.
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Acta Anaesthesiol Scand · Oct 2014
ReviewFibrinogen concentrate for bleeding - a systematic review.
Fibrinogen concentrate as part of treatment protocols increasingly draws attention. Fibrinogen substitution in cases of hypofibrinogenaemia has the potential to reduce bleeding, transfusion requirement and subsequently reduce morbidity and mortality. A systematic search for randomised controlled trials (RCTs) and non-randomised studies investigating fibrinogen concentrate in bleeding patients was conducted up to November 2013. ⋯ Weak evidence from RCTs supports the use of fibrinogen concentrate in bleeding patients, primarily in elective cardiac surgery, but a general use of fibrinogen across all settings is only supported by non-randomised studies with serious methodological shortcomings. It seems pre-mature to conclude whether fibrinogen concentrate has a routine role in the management of bleeding and coagulopathic patients. More RCTs are urgently warranted.