Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Jul 2014
A calibration study of SAPS II with Norwegian intensive care registry data.
Mortality prediction is important in intensive care. The Simplified Acute Physiology Score (SAPS) II is a tool for predicting such mortality. However, the original SAPS II is poorly calibrated to current intensive care unit (ICU) populations because it draws on data, which is more than 20 years old. We aimed to improve the calibration of SAPS II using data from the Norwegian Intensive Care Registry (NIR). This is the first recalibration of SAPS II for Nordic data. ⋯ As expected, Model B is better calibrated than Model A, and both models have similar uniformity of fit and equal discrimination. Introducing Model B into Norwegian ICUs may improve precision in decision-making. Units will have a more realistic benchmark for the assessment of ICU performance. Mortality risk estimates from Model B are better than previous SAPS II estimates have been.
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Acta Anaesthesiol Scand · Jul 2014
Review Meta AnalysisDexmedetomidine for preventing sevoflurane-related emergence agitation in children: a meta-analysis of randomized controlled trials.
Emergence agitation (EA) is a common problem after sevoflurane anesthesia in children. Prophylactic dexmedetomidine has been directed at this issue; however, the efficacy remains controversial. We therefore conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the effectiveness of dexmedetomidine on the incidence of sevoflurane-related EA. ⋯ Dexmedetomidine reduced the incidence of sevofurane-related EA (pooled RR = 0.351; 95% CI: 0.275-0.449; P = 0.965; heterogeneity test, I(2) = 0.0%), and it also resulted in a lower incidence of severe EA (pooled RR = 0.119; 95% CI: 0.033-0.422; P = 0.962; heterogeneity test, I(2) = 0.0%). All subgroup analyses for potential sources of heterogeneity showed a lower incidence of sevoflurane-related EA after dexmedetomidine administration. This meta-analysis demonstrated that dexemedetomidine was effective in reducing the incidence of sevoflurane-induced EA in children as compared with placebo.
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Acta Anaesthesiol Scand · Jul 2014
Randomized Controlled Trial Clinical TrialContinuous positive airway pressure/pressure support pre-oxygenation of morbidly obese patients.
Morbidly obese patients are more prone to desaturation of arterial blood during apnea with induction of anesthesia than are non-obese. This study aimed to assess the effect of low-pressure continuous positive airway pressure (CPAP) with pressure support ventilation (PSV) during pre-oxygenation on partial oxygen pressure in arterial blood (PaO2 ) immediately after tracheal intubation (post-intubation PaO2). ⋯ In morbidly obese patients, low-pressure CPAP combined with low-pressure PSV during pre-oxygenation resulted in better oxygenation, compared with neutral-pressure breathing, and prevented desaturation episodes.
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Acta Anaesthesiol Scand · Jul 2014
Randomized Controlled Trial Comparative StudyEffect of n-3 fatty acids on markers of brain injury and incidence of sepsis-associated delirium in septic patients.
Data regarding immunomodulatory effects of parenteral n-3 fatty acids in sepsis are conflicting. In this study, the effect of administration of parenteral n-3 fatty acids on markers of brain injury, incidence of sepsis-associated delirium, and inflammatory mediators in septic patients was investigated. ⋯ Administration of n-3 fatty acids did not affect markers of brain injury, incidence of sepsis-associated delirium, and inflammatory mediators in septic patients.
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Acta Anaesthesiol Scand · Jul 2014
Randomized Controlled Trial Comparative StudyPost-operative atelectasis - a randomised trial investigating a ventilatory strategy and low oxygen fraction during recovery.
Atelectasis is common during and after general anaesthesia. We hypothesized that a ventilation strategy with a combination of 1) continuous positive airway pressure (CPAP) or positive end-expiratory pressure (PEEP) and 2) a reduced end-expiratory oxygen concentration during recovery would reduce post-operative atelectasis. ⋯ Inducing anaesthesia with CPAP/PEEP and FIO2 1.0 and deliberately reducing FIO2 during recovery before removal of the LMA did not reduce post-operative atelectasis compared with FIO2 1.0 before removal of the LMA.