Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Feb 2015
Meta AnalysisEfficacy and safety of pregabalin for treating painful diabetic peripheral neuropathy: a meta-analysis.
Pregabalin is considered to be an effective treatment for painful diabetic peripheral neuropathy (DPN), but controversy exists about its efficacy and safety. We performed a meta-analysis to systematically assess the efficacy and safety of pregabalin for managing pain associated with DPN. ⋯ Our meta-analysis indicates that pregabalin is more effective than placebo for managing DPN-associated pain and other symptoms that reduce quality of life. The drug is also reasonably well tolerated.
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Acta Anaesthesiol Scand · Feb 2015
Randomized Controlled Trial Comparative StudyEmergence agitation after orthognathic surgery: a randomised controlled comparison between sevoflurane and desflurane.
This study aimed to compare emergence agitation following sevoflurane and desflurane anaesthesia in adults undergoing orthognathic surgery. The hypothesis was that there might be a difference in the incidence of emergence agitation following sevoflurane and desflurane anaesthesia considering the difference in blood solubility and speed of recovery between the two. ⋯ In adults undergoing orthognathic surgery, desflurane anaesthesia was associated with less emergence agitation than was sevoflurane anaesthesia.
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Acta Anaesthesiol Scand · Feb 2015
ReviewEndothelial dysfunction after non-cardiac surgery: a systematic review.
More than 50% of patients with increased troponin levels after non-cardiac surgery have an impaired endothelial function pre-operatively. Non-invasive markers of endothelial function have been developed for the assessment of endothelial dysfunction. The aim of this paper was to systematically review the literature to evaluate the association between non-cardiac surgery and non-invasive markers of endothelial function. ⋯ Endothelial function changes in relation to surgery. Assessment of endothelial function by non-invasive measures has the potential to guide clinicians in the prevention or treatment of post-operative myocardial damage.
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Acta Anaesthesiol Scand · Feb 2015
Randomized Controlled TrialIntranasal dexmedetomidine in combination with patient-controlled sedation during upper gastrointestinal endoscopy: a randomised trial.
Sedation using intranasal dexmedetomidine is a convenient and well-tolerated technique. This study evaluated the sedative efficacy of intranasal dexmedetomidine in combination with patient-controlled sedation (PCS) for upper gastrointestinal endoscopy. ⋯ Intranasal dexmedetomidine with PCS propofol and alfentanil confers deeper perioperative clinical sedation with significantly less use of additional sedatives during upper gastrointestinal endoscopy.
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Acta Anaesthesiol Scand · Feb 2015
The spread of injectate during saphenous nerve block at the adductor canal: a cadaver study.
The spread of injectate during a saphenous nerve block at the adductor canal has not been clearly described. ⋯ Injection of 15 ml dye was sufficient to spread throughout the adductor canal and beyond both proximally and distally. Distinct ultrasonographic features could be identified separating a subsartorial injection from an injection within the adductor canal with consequent differences in the spread.