Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Feb 2015
Meta AnalysisEfficacy and safety of pregabalin for treating painful diabetic peripheral neuropathy: a meta-analysis.
Pregabalin is considered to be an effective treatment for painful diabetic peripheral neuropathy (DPN), but controversy exists about its efficacy and safety. We performed a meta-analysis to systematically assess the efficacy and safety of pregabalin for managing pain associated with DPN. ⋯ Our meta-analysis indicates that pregabalin is more effective than placebo for managing DPN-associated pain and other symptoms that reduce quality of life. The drug is also reasonably well tolerated.