Journal of neuroimaging : official journal of the American Society of Neuroimaging
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Review Multicenter Study
Endovascular management of symptomatic extracranial stenosis associated with secondary intracranial tandem stenosis. A multicenter review.
Several studies have reported variable rates of perioperative risk of stroke in individuals with tandem stenoses after carotid endarterectomy. Endovascular treatment of extracranial lesions associated with tandem lesions is limited to case reports and small case series. ⋯ The high risk of postprocedural stroke and/or death observed in this series requires careful assessment of the risk/benefit ratio of endovascular procedures in patients with tandem stenosis.
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Multicenter Study Clinical Trial
Intra-arterial tenecteplase for treatment of acute ischemic stroke: feasibility and comparative outcomes.
Tenecteplase (TNK) is a third-generation thrombolytic agent. We evaluated the safety and feasibility of intra-arterial (IA) administration of TNK in patients with acute ischemic stroke. ⋯ Our study demonstrates that administration of IA TNK in acute stroke is safe and results in rates of favorable outcomes that are comparable to those observed with currently used drugs. Additional studies are needed to further determine the safety and efficacy of IA TNK in acute stroke treatment.