Journal of neuroimaging : official journal of the American Society of Neuroimaging
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Multicenter Study Clinical Trial
Intra-arterial tenecteplase for treatment of acute ischemic stroke: feasibility and comparative outcomes.
Tenecteplase (TNK) is a third-generation thrombolytic agent. We evaluated the safety and feasibility of intra-arterial (IA) administration of TNK in patients with acute ischemic stroke. ⋯ Our study demonstrates that administration of IA TNK in acute stroke is safe and results in rates of favorable outcomes that are comparable to those observed with currently used drugs. Additional studies are needed to further determine the safety and efficacy of IA TNK in acute stroke treatment.
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Practice Guideline
Practice standards for transcranial Doppler (TCD) ultrasound. Part II. Clinical indications and expected outcomes.
Transcranial Doppler (TCD) is a physiological ultrasound test with established safety and efficacy. Although imaging devices may be used to depict intracranial flow superimposed on structural visualization, the end-result provided by imaging duplex or nonimaging TCD is sampling physiological flow variables through the spectral waveform assessment. ⋯ By defining the scope of practice, these standards will assist referring and reporting physicians and third parties involved in the process of requesting, evaluating, and acting upon TCD results.
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Our institution serves a population of 160,000 and performed 14.4 endovascular cerebral aneurysm interventions annually, averaged over a 5-year period. The purpose of this study was to examine the safety and efficacy of endovascular treatment of cerebral aneurysms at a lowvolume center. ⋯ Endovascular coil embolization at a small volume nonspecialized community center is feasible with satisfactory procedural risk and clinical outcomes.
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The acquisition of literacy during childhood may affect the functional organization of the brain. We studied the effects of illiteracy on neuropsychological tests and brain glucose metabolism in later life. ⋯ These results suggest that reading and writing during childhood is associated with activation of the frontal pole that may play a critical role in complex aspects of human cognition.