American heart journal
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American heart journal · Jun 2008
Randomized Controlled TrialUtility of N-acetylcysteine to prevent acute kidney injury after cardiac surgery: a randomized controlled trial.
Acute kidney injury (AKI) after heart surgery is associated with increased mortality. We sought to determine whether prophylactic perioperative administration of N-acetylcysteine (NAC) prevents postoperative AKI in patients with chronic kidney disease undergoing cardiac surgery (clinical trials.gov identifier NCT00211653). ⋯ Prophylactic perioperative NAC administration does not prevent AKI after cardiac surgery.