The Annals of pharmacotherapy
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N-nitrosodimethylamine (NDMA) is a hepatotoxic agent and carcinogen contaminant in commonly used medications such as valsartan, losartan, irbesartan, and ranitidine. NDMA can be produced during manufacture, introduced from contaminated ingredients procured elsewhere, or introduced from contaminated solvents and catalysts. The Food and Drug Administration has established a maximum dose of NDMA that is permissible per tablet and guidance for manufacturers. However, many unanswered questions about NDMA contamination need rigorous investigation.
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Editorial Review Comparative Study
Human papillomavirus quadrivalent vaccine: a look behind the numbers.
The human papillomavirus (HPV) quadrivalent vaccine was licensed in 2006 for prevention of cervical, vulvar, and vaginal cancers caused by HPV-16 and -18 and genital warts caused by HPV-6 and -11. It is also indicated for prevention of precancerous and dysplastic lesions caused by HPV-6, -11, -16, and -18. ⋯ Careful consideration should be given to these issues by pharmacy and pharmacy professional organizations. To formulate reasonable healthcare guidelines, pharmacists and other healthcare professionals will need to engage policymakers in conversations concerning the vaccine's merits or limitations and the economic impact.
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Peer reviewed publications are the primary source of important new information. This editorial provides tips for writing various sections of research papers, review articles, and case reports. Additional topics discussed include making decisions about authorship, selecting a journal for submission of an article, understanding the peer review process and expectations of editors and reviewers, and revising the article. Successful authors combine appropriate knowledge and experience, personal attributes, and effective collaborations to produce insightful and important contributions to the literature.