Osteoarthritis and cartilage
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Osteoarthr. Cartil. · Nov 2004
Multicenter Study Clinical TrialResponsiveness of the electronic touch screen WOMAC 3.1 OA Index in a short term clinical trial with rofecoxib.
The Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index is a self-administered validated questionnaire for patients with osteoarthritis (OA) of the hip or knee. The electronic touch screen version of the WOMAC (e-WOMAC) has been previously shown to be highly correlated with the original paper format. However, whether the e-WOMAC would be suitable for monitoring the effects of drug treatment is unknown. ⋯ In this longitudinal intervention study, the e-WOMAC OA Index 3.1 showed similar responsiveness in detecting clinically meaningful changes than the original paper format.
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Osteoarthr. Cartil. · Aug 2004
Randomized Controlled Trial Multicenter Study Clinical TrialEfficacy and safety of a single intra-articular injection of non-animal stabilized hyaluronic acid (NASHA) in patients with osteoarthritis of the knee.
Non-animal stabilized hyaluronic acid (NASHA) is a novel hyaluronan (HA) preparation with a 4-week intra-articular half-life. This study compared the efficacy of a single injection of NASHA with placebo in patients with osteoarthritis (OA) of the knee. ⋯ NASHA was not superior to placebo for the primary efficacy analysis. However, these data may be confounded by the inclusion of patients with OA at other sites, as significant benefits over placebo were found among patients with OA confined to the knee. Future trials of OA that examine a local therapy might need to consider restricting the study population to those patients having OA of only the signal joint.
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Osteoarthr. Cartil. · May 2004
Multicenter StudyTwo knees or not two knees? Patient costs and outcomes following bilateral and unilateral total knee joint replacement surgery for OA.
This study aims to address medical and non-medical direct costs and health outcomes of bilateral and unilateral total knee replacement from the patients' perspective during the first year post-surgery. ⋯ Patients undergoing bilateral TKR and unilateral TKR had a similar length of stay in hospital and similar out-of-pocket expenditures. Bilateral replacement patients reported better physical function and general health with fewer health care visits one year post procedure. Patients requiring bilateral TKR have some additional information to aid their decision making. While their risk of peri-operative complications is higher, they have an excellent chance of good health outcomes at 12 months and are not going to be doubly "out-of-pocket" for the experience.
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Osteoarthr. Cartil. · Mar 2004
Multicenter Study Comparative StudyRelative efficiency and validity properties of a visual analogue vs a categorical scaled version of the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) Index: Spanish versions.
To compare the performance of visual analogue (VAS) vs categorical (CT) scaled versions of the three subscales (pain, stiffness and difficulty) of the WOMAC Index in patients with knee osteoarthritis. ⋯ We have shown that both the VAS version of WOMAC have adequate evaluative and discriminative properties. We found the pain and physical function scales in VAS format and the stiffness scale in CT format to have a slightly better performance in this sample.